Herein we describe an unprecedented RuII-catalyzed site-selective and regiospecific annulation of benzoic acids with propargylic carbonates. The weakly coordinating carboxylic acid moiety outperformed other typically used directing groups in C–H activation, including ketone, nitrile, sulfonamide, amide and strongly coordinating nitrogen heterocycles. This is an important step towards the application of C–H activation reactions in complex (functional) real-world molecules.
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机译：本文中，我们描述了前所未有的Ru II 催化苯甲酸与炔丙基碳酸酯的位点选择性和区域专一性环化反应。在CH活化中，弱配位的羧酸部分优于其他常用的直接基团，包括酮，腈，磺酰胺，酰胺和强配氮杂环。这是在复杂的（功能性）现实世界分子中应用C–H活化反应的重要一步。
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