首页> 美国卫生研究院文献>Clinical and Experimental Gastroenterology >High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection
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High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection

机译:成人囊性纤维化血清中难辨梭状芽孢杆菌毒素的亚类特异性结合和中和抗体盛行:针对有症状艰难梭菌感染的免疫保护方式

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摘要

ObjectivesDespite multiple risk factors and a high rate of colonization for Clostridium difficile, the occurrence of C. difficile infection in patients with cystic fibrosis is rare. The aim of this study was to compare the prevalence of binding C. difficile toxin-specific immunoglobulin (Ig)A, IgG and anti-toxin neutralizing antibodies in the sera of adults with cystic fibrosis, symptomatic C. difficile infection (without cystic fibrosis) and healthy controls.
机译:目的尽管艰难梭菌存在多种危险因素和高定殖率,但囊性纤维化患者很少发生艰难梭菌感染。这项研究的目的是比较在患有囊性纤维化,有症状的艰难梭菌感染(无囊性纤维化)的成年人血清中,结合艰难梭菌毒素特异性免疫球蛋白(Ig)A,IgG和抗毒素中和抗体的患病率和健康的控制。

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