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MK-801 Upregulates NR2A Protein Levels and Induces Functional Recovery of the Ipsilateral Hemidiaphragm Following Acute C2 Hemisection in Adult Rats

机译：MK-801上调NR2A蛋白水平并诱导成年大鼠急性C2半切后同侧半He的功能恢复

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摘要

Background:C2 hemisection results in paralysis of the ipsilateral hemidiaphragm. Recent data indicate that an upregulation of the N-methyl-d-aspartate (NMDA) receptor 2A subunit following chronic C2 hemisection is associated with spontaneous hemidiaphragmatic recovery following injury. MK-801, an antagonist of the NMDA receptor, upregulates the NR2A subunit in neonatal rats.

机译：背景：C2半切导致同侧半ia瘫痪。最新数据表明，慢性C2半切后N-甲基-d-天冬氨酸（NMDA）受体2A亚基的上调与损伤后自发的he肌恢复有关。 NMDA受体的拮抗剂MK-801上调新生大鼠的NR2A亚基。

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期刊名称 The Journal of Spinal Cord Medicine
作者
Warren J Alilain; Harry G Goshgarian;
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作者单位

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年(卷),期 2007(30),4
年度 2007
页码 346–354
总页数 9
原文格式 PDF
正文语种
中图分类神经病学;
关键词
C2 hemisection Spinal cord injuries Motor recovery Phrenic nucleus Plasticity Long-term potentiation N-methyl-d-aspartate (NMDA) MK-801 NMDA-receptor antagonist;

机译：C2半切;脊髓损伤;运动恢复;Ph核;可塑性;长期增强作用;N-甲基-d-天门冬氨酸（NMDA）;MK-801;NMDA受体拮抗剂;

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专利

1. MK-801 Upregulates NR2A Protein Levels and Induces Functional Recovery of the Ipsilateral Hemidiaphragm Following Acute C2 Hemisection in Adult Rats [J] . Warren J Alilain, Harry G Goshgarian The journal of spinal cord medicine . 2007,第4期

机译：MK-801上调NR2A蛋白水平并诱导成年大鼠急性C2半切后同侧半ia的功能恢复
2. Injection of WGA-Alexa 488 into the ipsilateral hemidiaphragm of acutely and chronically C2 hemisected rats reveals activity-dependent synaptic plasticity in the respiratory motor pathways [J] . Buttry Janelle L., Goshgarian Harry G. Experimental Neurology . 2014,第Null期

机译：将WGA-Alexa 488注射到急慢性C2偏侧大鼠的同侧半ph中，发现其在呼吸运动通路中的活性依赖于突触可塑性
3. Theophylline-induced recovery in a hemidiaphragm paralyzed by hemisection in rats: contribution of adenosine receptors. [J] . Nantwi KD, Goshgarian HG Neuropharmacology . 1998,第1期

机译：茶碱诱导的大鼠半ph瘫痪的半ph中的恢复：腺苷受体的贡献。
4. Spontaneous Functional Recovery Induced By Remaining Spinal fibers After Spinal Cord Transection in Adult Rats [C] . Siwei You, Bingyao Chen, Huiling Liu, Third International Conference of China on Anatomical Sciences Sep 21-24, 2001 Nantong, China . 2001

机译：成年大鼠脊髓横断后剩余脊髓纤维引起的自发功能恢复
5. Effects of sodium thiosulfate antidotal action against subacute acrylonitrile exposure in male rats: Modulation of glial fibrillary acidic protein and glutathione levels [D] . Enongene, Evaristus Nsang 1998

机译：硫代硫酸钠解毒作用对雄性大鼠亚急性丙烯腈暴露的影响：胶质纤维酸性蛋白和谷胱甘肽水平的调节
6. Continuous administration of a p38α inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level [O] . John J. Alam, Michael Krakovsky, Ursula Germann, 2020

机译：在大鼠中瞬时缺血诱导的卒中后的亚硫缺失期间连续给予p38α抑制剂促进剂量依赖性功能恢复伴随脑BDNF蛋白水平的增加
7. Continuous administration of a p38α inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level [O] . John J. Alam, Michael Krakovsky, Ursula Germann, 2020

机译：在大鼠中瞬时缺血诱导的卒中后的亚硫缺失期间连续给予p38α抑制剂促进剂量依赖性功能恢复伴随脑BDNF蛋白水平的增加

MK-801 Upregulates NR2A Protein Levels and Induces Functional Recovery of the Ipsilateral Hemidiaphragm Following Acute C2 Hemisection in Adult Rats

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