Clinical examination, bronchoalveolar lavage fluid (BALF) cytology, acute-phase protein, and pulmonary hemostasis and fibrinolysis marker (fibrinogen, serum amyloid A [SAA], and D-dimer) results were compared between control and respiratory disease-affected horses. Using a clinical scoring system, horses (n = 58) were classified as respiratory disease-free (Controls, n = 15) or with recurrent airway obstruction (RAO; n = 18), inflammatory airway disease (n = 14) or chronic interstitial pneumopathy (n = 11). There were no significant differences in fibrinogen concentrations among groups, but there was a trend toward a lower value in controls (median 0.0024 g/L) than in horses with chronic pneumopathies (median 0.0052 g/L), in particular, those with RAO (median 0.0062 g/L). Fibrinogen concentration was positively correlated with percentage of neutrophils in BALF (rs = 0.377, p = 0.004). SAA concentrations were low; 65.5% of samples were below the detection limit. D-dimer concentrations were also low and quantifiable concentrations were only obtained after ultrafiltration and only in RAO (median 0.1 mg/L). In conclusion, there was limited evidence of increased coagulatory activity in chronic pneumopathies, apart from RAO. It is uncertain whether fibrinogen and D-dimer concentrations increased due to their role as acute-phase proteins or as a misbalance of coagulation and fibrinolysis.
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机译:比较了对照组和受呼吸系统疾病影响的马的临床检查,支气管肺泡灌洗液(BALF)的细胞学,急性期蛋白以及肺部止血和纤维蛋白溶解标记物(纤维蛋白原,血清淀粉样蛋白A [SAA]和D-二聚体)的结果。使用临床评分系统,将马(n = 58)划分为无呼吸系统疾病(对照组,n = 15)或患有复发性气道阻塞(RAO; n = 18),炎性气道疾病(n = 14)或慢性间质性肺病(n = 11)。各组之间的纤维蛋白原浓度没有显着差异,但对照组中值(0.0024 g / L)的趋势要比患有慢性肺气病(中位数0.0052 g / L)的马,特别是那些患有RAO(中值0.0062 g / L)。纤维蛋白原浓度与BALF中的中性粒细胞百分比呈正相关(rs = 0.377,p = 0.004)。 SAA浓度低; 65.5%的样品低于检测极限。 D-二聚体的浓度也很低,只有超滤后才能得到可定量的浓度,并且只能以RAO(中值0.1 mg / L)获得。总之,除RAO之外,在慢性气肿中凝血活性增加的证据有限。尚不确定纤维蛋白原和D-二聚体的浓度是否由于其作为急性期蛋白的作用或由于凝血和纤维蛋白溶解失衡而增加。
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