首页> 美国卫生研究院文献>Journal of Toxicologic Pathology >Unchanged Distribution Density of Anionic Sites on the Glomerular Wall in Rats with Active Heymann Nephritis
【2h】

Unchanged Distribution Density of Anionic Sites on the Glomerular Wall in Rats with Active Heymann Nephritis

机译:活动性Heymann肾炎大鼠肾小球壁阴离子位点的分布密度不变

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

In various kinds of glomerulonephritis, alteration of anionic charge on the glomerular basement membrane (GBM) and podocytes has been controversial for more than decade. To elucidate the relation between glomerular protein leakage and anionic sites on the glomerular wall, we examined the distribution of anionic sites on the GBM and podocytes of rats with active Heymann nephritis (AHN). Urinalysis for protein levels was conducted, and the kidneys were examined using electron microscopic cytochemistry for the assessment of anionic charge with two cationic probes. The anionic sites on podocytes were decreased in number in the AHN rats; however, the distributions of anionic sites on the GBM were similar in density to those seen in the control animals. From these results, we consider that the decrease in anionic charge density on podocytes might be attributable to protein leakage and that the charge barrier of the GBM is irrelevant to the protein leakage in AHN rats.
机译:在各种肾小球肾炎中,肾小球基底膜(GBM)和足细胞上的阴离子电荷的变化已引起争议十多年。为了阐明肾小球蛋白渗漏与肾小球壁上阴离子位点之间的关系,我们检查了患有活动性Heymann肾炎(AHN)大鼠的GBM和足细胞中阴离子位点的分布。进行尿液蛋白水平检测,并使用电子显微镜细胞化学检查肾脏,以使用两个阳离子探针评估阴离子电荷。 AHN大鼠足细胞上的阴离子位点数量减少;然而,GBM上阴离子位点的分布密度与对照组动物相似。从这些结果,我们认为足细胞上阴离子电荷密度的降低可能归因于蛋白质的泄漏,而GBM的电荷屏障与AHN大鼠中的蛋白质的泄漏无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号