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Glucose Concentration Measurement in Human Blood Plasma Solutions with Microwave Sensors

机译:微波传感器测量人血浆溶液中的葡萄糖浓度

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摘要

Three microwave sensors are used to track the glucose level of different human blood plasma solutions. In this paper, the sensors are evaluated as glucose trackers in a context close to real human blood. Different plasma solutions sets were prepared from a human blood sample at several added glucose concentrations up to 10 wt%, adding also ascorbic acid and lactic acid at different concentrations. The experimental results for the different sensors/solutions combinations are presented in this work. The sensors show good performance and linearity as glucose level retrievers, although the sensitivities change as the rest of components vary. Different sensor behaviors depending upon the concentrations of glucose and other components are identified and characterized. The results obtained in terms of sensitivity are coherent with previous works, highlighting the contribution of glucose to the dielectric losses of the solution. The results are also consistent with the frequency evolution of the electromagnetic signature of glucose found in the literature, and are helpful for selecting frequency bands for sensing purposes and envisioning future approaches to the challenging measurement in real biological contexts. Discussion of the implications of the results and guidelines for further research and development of more accurate sensors is offered.
机译:三个微波传感器用于跟踪不同人体血浆溶液的葡萄糖水平。在本文中,传感器在接近真实人类血液的环境中被评估为葡萄糖追踪器。从人类血液样品中以几种添加的葡萄糖浓度(至多10 wt%)制备了不同的血浆溶液组,还添加了不同浓度的抗坏血酸和乳酸。在这项工作中介绍了不同传感器/解决方案组合的实验结果。这些传感器表现出良好的性能和线性度,可作为葡萄糖水平检索器,尽管灵敏度会随着其余成分的变化而变化。识别并表征了取决于葡萄糖和其他成分的浓度的不同传感器行为。在灵敏度方面获得的结果与以前的工作相一致,突出了葡萄糖对溶液介电损耗的贡献。该结果也与文献中发现的葡萄糖的电磁特征的频率演变一致,并且有助于选择用于感测目的的频带并设想未来在实际生物学环境中进行具有挑战性的测量的方法。讨论了结果和准则对进一步研究和开发更精确的传感器的影响。

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