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Therapeutic Immunization with a Mixture of Herpes Simplex Virus 1 Glycoprotein D-Derived Asymptomatic Human CD8+ T-Cell Epitopes Decreases Spontaneous Ocular Shedding in Latently Infected HLA Transgenic Rabbits: Association with Low Frequency of Local PD-1+ TIM-3+ CD8+ Exhausted T Cells

机译：单纯疱疹病毒1糖蛋白D衍生的无症状人类CD8 + T细胞表位的混合物的治疗性免疫减少了潜伏感染HLA转基因兔的自发眼脱落：与局部PD-1 + TIM-3 + CD8 +疲乏的低频率相关T细胞

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期刊名称 Journal of Virology
作者
Arif A. Khan; Ruchi Srivastava; Aziz A. Chentoufi; Roger Geertsema; Nhi Thi Uyen Thai; Gargi Dasgupta; Nelson Osorio; Mina Kalantari; Anthony B. Nesburn; Steven L. Wechsler; Lbachir BenMohamed;
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作者单位

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年(卷),期 2015(89),13
年度 2015
页码 6619–6632
总页数 14
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
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外文文献

1. A Herpes Simplex Virus Type 1 Human Asymptomatic CD8+ T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a a??Humanizeda?? HLA Transgenic Rabbit Model [J] . Ruchi Srivastava, Arif A. Khan, Jiawei Huang, Investigative ophthalmology & visual science . 2015,第6期

机译：一种基于单纯疱疹病毒的1型无症状CD8 + T细胞抗原决定簇的疫苗可预防人疱疹病毒感染的眼疱疹。 HLA转基因兔模型
2. Asymptomatic HLA-A*02:01–Restricted Epitopes from Herpes Simplex Virus Glycoprotein B Preferentially Recall Polyfunctional CD8+ T Cells from Seropositive Asymptomatic Individuals and Protect HLA Transgenic Mice against Ocular Herpes [J] . Xavier Dervillez, Huma Qureshi, Aziz A. Chentoufi, The journal of immunology . 2013,第10期

机译：无症状HLA-A * 02：01 –单纯疱疹病毒糖蛋白B的限制性表位优先召回血清反应阳性无症状个体的多功能CD8 + T细胞，并保护HLA转基因小鼠免于眼疱疹的侵害
3. HLA-A02:01–Restricted Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP11/12 Preferentially Recall Polyfunctional Effector Memory CD8+ T Cells from Seropositive Asymptomatic Individuals and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpes [J] . Ruchi Srivastava, Arif A. Khan, Doran Spencer, The journal of immunology . 2015,第5期

机译：HLA-A02：01 –从单纯疱疹病毒外皮蛋白VP11 / 12中鉴定出的限制性抗原决定簇可以优先召回来自血清阳性无症状个体的多功能效应记忆CD8 + T细胞，并保护人源化HLA-A * 02：01转基因小鼠免受眼疱疹的侵害
4. A Herpes Simplex Virus Type 1 Human Asymptomatic CD8+ T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a Humanized HLA Transgenic Rabbit Model [O] . Ruchi Srivastava, Arif A. Khan, Jiawei Huang, -1

机译：一种基于单纯型疱疹病毒的人类无症状CD8 + T细胞抗原决定簇的疫苗可在人源化 HLA转基因兔模型中预防眼疱疹
5. Asymptomatic HLA-A*02:01–Restricted Epitopes from Herpes Simplex Virus Glycoprotein B Preferentially Recall Polyfunctional CD8+T Cells from Seropositive Asymptomatic Individuals and Protect HLA Transgenic Mice against Ocular Herpes [O] . Xavier Dervillez, Huma Qureshi, Aziz A. Chentoufi, 2013

机译：无症状HLA-A * 02：01疱疹病毒糖蛋白B的受限制表位，优先调查从血清阳性无症状个体的多官能CD8 + T细胞，并保护HLA转基因小鼠免受眼疱疹的影响

Therapeutic Immunization with a Mixture of Herpes Simplex Virus 1 Glycoprotein D-Derived Asymptomatic Human CD8+ T-Cell Epitopes Decreases Spontaneous Ocular Shedding in Latently Infected HLA Transgenic Rabbits: Association with Low Frequency of Local PD-1+ TIM-3+ CD8+ Exhausted T Cells

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