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Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer

机译：瑞戈非尼联合水飞蓟宾作为治疗转移性结直肠癌的新潜在策略

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PurposeRegorafenib, an oral multikinase inhibitor, has demonstrated survival benefit in metastatic colorectal cancer (mCRC) patients that have progressed after all standard therapies. However, novel strategies to improve tolerability and enhance anti-cancer efficacy are needed.

机译：目的Regorafenib是一种口服多激酶抑制剂，已证明在所有标准疗法后均进展的转移性结直肠癌（mCRC）患者中具有生存获益。然而，需要改善耐受性和增强抗癌功效的新策略。

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期刊名称 Oncotarget
作者
Valentina Belli; Vincenzo Sforza; Claudia Cardone; Erika Martinelli; Giusi Barra; Nunzia Matrone; Stefania Napolitano; Floriana Morgillo; Concetta Tuccillo; Alessandro Federico; Marcello Dallio; Carmelina Loguercio; Antonietta Gerarda Gravina; Raffaele De Palma; Fortunato Ciardiello; Teresa Troiani;
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作者单位

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年(卷),期 2017(8),40
年度 2017
页码 68305–68316
总页数 12
原文格式 PDF
正文语种
中图分类肿瘤学;细胞生物学;
关键词
metastatic colorectal cancer (mCRC) regorafenib silybin reactive oxygen species (ROS);

机译：转移性结直肠癌（mCRC）;雷戈非尼;水飞蓟宾;活性氧（ROS）;

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专利

1. Regorafenib with a fluoropyrimidine for metastatic colorectal cancer after progression on multiple 5-FU-containing combination therapies and regorafenib monotherapy [J] . Marks Eric I., Tan Carlyn, Zhang Jun, Cancer biology & therapy . 2015,第12期

机译：雷戈非尼联合氟嘧啶用于转移性结直肠癌的多种含5-FU联合疗法和雷戈非尼单药治疗后
2. A phase Ib study of the combination regorafenib with PF-03446962 in patients with refractory metastatic colorectal cancer (REGAL-1 trial) [J] . Clarke Jeffrey Melson, Blobe Gerard C., Strickler John H., Cancer chemotherapy and pharmacology. . 2019,第4期

机译：难治性转移性结直肠癌患者的PF-03446962与PF-03446962相相IB研究（Regal-1试验）
3. Proactive strategies for regorafenib in metastatic colorectal cancer: implications for optimal patient management [J] . Gazala Khan, Rebecca A Moss, Fadi Braiteh, Cancer Management and Research . 2014,第2016期

机译：雷格非尼在转移性结直肠癌中的积极策略：对最佳患者管理的意义
4. A high-throughput fully-automated microfluidic live cell array for combination drug treatment analysis of colorectal cancer cells [C] . Wang H., Kim J., Jayaraman A., The 16th International Conference on olid-State Sensors, Actuators and Microsystems . 2011

机译：用于大肠癌细胞联合药物治疗分析的高通量全自动微流活细胞阵列
5. Enhancement of Gemcitabine and Paclitaxel Uptake and Retention in Metastatic Cancer Cells: A Novel Targeted Combination Delivery Approach to Eliminate Breast Cancer in Blood and Lymph [D] . Yu, Jesse. 2020

机译：吉西他滨和紫杉醇吸收的增强和转移性癌细胞的保留：一种小型靶向组合递送方法，消除血液和淋巴中的乳腺癌
6. Regorafenib with a fluoropyrimidine for metastatic colorectal cancer after progression on multiple 5-FU-containing combination therapies and regorafenib monotherapy [O] . Eric I. Marks, Carlyn Tan, Jun Zhang, 2015

机译：雷戈非尼联合氟嘧啶用于转移性结直肠癌的多种含5-FU联合疗法和雷戈非尼单药治疗后进展
7. Regorafenib with a fluoropyrimidine for metastatic colorectal cancer after progression on multiple 5-FU-containing combination therapies and regorafenib monotherapy [O] . Eric I. Marks, Carlyn Tan, Jun Zhang, 2015

机译：Regorafenib与氟嘧啶用于转移性结直肠癌的含量后多个5富含5富富福组合治疗和雄育单疗法

Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer

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