Arsenic trioxide-mediated oxidative stress and genotoxicity in human hepatocellular carcinoma cells

摘要

BackgroundArsenic is a ubiquitous environmental toxicant, and abnormalities of the skin, lung, kidney, and liver are the most common outcomes of long-term arsenic exposure. This study was designed to investigate the possible mechanisms of genotoxicity induced by arsenic trioxide in human hepatocellular carcinoma cells.