Apple pectin a dietary fiber ameliorates myocardial injury by inhibiting apoptosis in a rat model of ischemia/reperfusion

摘要

BACKGROUND/OBJECTIVEMyocardial cell death due to occlusion of the coronary arteries leads to myocardial infarction, a subset of coronary heart disease (CHD). Dietary fiber is known to be associated with a reduced risk of CHD, the underlying mechanisms of which were suggested to delay the onset of occlusion by ameliorating risk factors. In this study, we tested a hypothesis that a beneficial role of dietary fiber could arise from protection of myocardial cells against ischemic injury, manifested after occlusion of the arteries.