ATIM-06. A PILOT STUDY OF STEREOTACTIC RADIOSURGERY (SRS) COMBINED WITH IPILIMUMAB PROLONGED SURVIVAL IN PATIENTS WITH NEWLY DIAGNOSED MELANOMA BRAIN METASTASES

摘要

BACKGROUNDPre-clinical and clinical data have shown that administering a high dose of radiation (SRS) directly to a tumor up-regulates MHC expression and pro-inflammatory cytokines in the tumor microenvironment. Studies have suggested that SRS works synergistically with checkpoint inhibitors to improve an antitumor immune response. We examined the combination of ipilimumab with SRS in patients with melanoma brain metastases.