Development of novel LOXL1 genotyping method and evaluation of LOXL1 APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population

摘要

PurposeIn the Greek population of Epirus, exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) occur at a high prevalence. In this study, we validate a novel lysyl oxidase-like 1 (LOXL1) genotyping method, investigate the previously reported association of LOXL1 with XFS/XFG, and evaluate apolipoprotein E (APOE) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms as genetic risk factors for both conditions in our population.