Synthesis of Novel Homo-N-Nucleoside Analogs Composed of a Homo-14-Dioxane Sugar Analog and Substituted 135-Triazine Base Equivalents

摘要

Enantioselective syntheses from dimethyl tartrate of 1,3,5-triazine homo-N-nucleoside analogs, containing a 1,4-dioxane moiety replacing the sugar unit in natural nucleosides, were accomplished. The triazine heterocycle in the nucleoside analogs was further substituted with combinations of NH2, OH and Cl in the 2,4-triazine positions.