Knockdown of the Sonic Hedgehog (SHH) Gene Inhibits Proliferation of Hep3B and SMMC-7721 Hepatocellular Carcinoma Cells via the PI3K/Akt/PCK1 Signaling Pathway

机译：敲除声波刺猬（SHH）基因通过PI3K / Akt / PCK1信号通路抑制Hep3B和SMMC-7721肝癌细胞的增殖

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BackgroundThe PCK1 gene encodes phosphoenolpyruvate carboxykinase (PEPCK), which has been shown have a role in metabolic events in hepatocellular carcinoma (HCC). This study aimed to investigate the role of the SHH gene and its encoded protein, sonic hedgehog (SHH), in two human hepatocellular carcinoma (HCC) cell lines.

机译：背景PCK1基因编码磷酸烯醇丙酮酸羧激酶（PEPCK），已显示在肝细胞癌（HCC）的代谢事件中具有作用。这项研究旨在调查SHH基因及其编码的蛋白，声波刺猬（SHH）在两种人类肝细胞癌（HCC）细胞系中的作用。

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Youping Chen; Weifang Zhu;
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年(卷),期 2019(25),-1
年度 2019
页码 6023–6033
总页数 11
原文格式 PDF
正文语种
中图分类
关键词
Hedgehog Proteins Liver Neoplasms Phosphatidylinositol 3-Kinases Phosphoenolpyruvate Carboxykinase (ATP);

机译：刺猬蛋白;肝脏肿瘤;磷脂酰肌醇3-激酶;磷酸烯醇丙酮酸羧化激酶（ATP）;

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专利

1. Knockdown of HPIP Inhibits the Proliferation and Invasion of Head-and-Neck Squamous Cell Carcinoma Cells by Regulating PI3K/Akt Signaling Pathway [J] . Chen Yangjing, Zhao Ruimin, Zhao Qian, Oncology Research . 2016,第3期

机译：抑制HPIP通过调节PI3K / Akt信号通路抑制头颈部鳞状细胞癌细胞的增殖和侵袭
2. Axl gene knockdown inhibits the metastasis properties of hepatocellular carcinoma via PI3K/Akt-PAK1 signal pathway [J] . XuJ., JiaL., MaH., Tumour biology : . 2014,第4期

机译：Axl基因敲低通过PI3K / Akt-PAK1信号通路抑制肝细胞癌的转移特性
3. Knockdown of CLDN6 inhibits cell proliferation and migration via PI3K/AKT/mTOR signaling pathway in endometrial carcinoma cell line HEC-1-B [J] . Xia Cao, Guo-Zhao He OncoTargets and therapy . 2018,第1期

机译：敲低CLDN6通过PI3K / AKT / mTOR信号通路抑制子宫内膜癌细胞株HEC-1-B中的细胞增殖和迁移
4. Screening of Sonic Hedgehog (Shh) Inhibitors in the Hedgehog Signaling Pathway from Traditional Chinese Medicine (TCM) Database Through Structure-Based Pharmacophore Design [C] . Ilmi Fadhilah Rizki, Mochammad Arfin Fardiansyah Nasution, Syafrida Siregar, International symposium on bioinformatics research and applications . 2018

机译：基于结构药理设计的中药（TCM）数据库中刺猬信号通路中声波刺猬（Shh）抑制剂的筛选
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. PCDH10 gene inhibits cell proliferation and induces cell apoptosis by inhibiting the PI3K/Akt signaling pathway in hepatocellular carcinoma cells [O] . Mingxin Ye, Jinzheng Li, Jianping Gong -1

机译：PCDH10基因通过抑制肝癌细胞中的PI3K / Akt信号通路抑制细胞增殖并诱导细胞凋亡
7. Knockdown of the Sonic Hedgehog (SHH) Gene Inhibits Proliferation of Hep3B and SMMC-7721 Hepatocellular Carcinoma Cells via the PI3K/Akt/PCK1 Signaling Pathway [O] . Youping Chen, Weifang Zhu 2019

机译：Sonic Hedgehog（SHH）基因的敲低通过PI3K / AKT / PCK1信号传导途径抑制HEP3B和SMMC-7721肝细胞癌细胞的增殖

Knockdown of the Sonic Hedgehog (SHH) Gene Inhibits Proliferation of Hep3B and SMMC-7721 Hepatocellular Carcinoma Cells via the PI3K/Akt/PCK1 Signaling Pathway

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