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Senkyunolide A protects neural cells against corticosterone-induced apoptosis by modulating protein phosphatase 2A and α-synuclein signaling

机译：Senkyunolide A通过调节蛋白磷酸酶2A和α-突触核蛋白信号转导保护神经细胞免受皮质酮诱导的凋亡

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摘要

BackgroundDepression is characterized by a pathological injury to the hippocampal neurons. Senkyunolide A (SenA) is one of the major active components of Dan-zhi-xiao-yao-san, which is widely used in the treatment of depression-related disorders.

机译：背景抑郁症的特征是海马神经元受到病理性损伤。 Senkyunolide A（SenA）是Dan-zhi-xiao-yaosan的主要活性成分之一，被广泛用于治疗与抑郁症相关的疾病。

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期刊名称 Drug Design Development and Therapy
作者
Shenglan Gong; Jin Zhang; Zhouke Guo; Wenjun Fu;
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作者单位

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年(卷),期 2018(12),-1
年度 2018
页码 1865–1879
总页数 15
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
α-synuclein corticosterone depression neuroprotection protein phosphatase 2A senkyunolide A;

机译：α-突触核蛋白;皮质酮;抑郁症;神经保护;蛋白磷酸酶2A;senkyunolide A;

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专利

1. Senkyunolide A protects neural cells against corticosterone-induced apoptosis by modulating protein phosphatase 2A and α-synuclein signaling [J] . Shenglan Gong, Jin Zhang, Zhouke Guo, Drug Design, Development and Therapy . 2018,第InaProgress期

机译：Senkyunolide A通过调节蛋白磷酸酶2A和α-突触核蛋白信号转导保护神经细胞免受皮质酮诱导的凋亡
2. The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells [J] . RuvoloP.P., RuvoloV.R., JacamoR., Biochimica et biophysica acta. Molecular cell research . 2014,第9期

机译：蛋白磷酸酶2A调节亚基B55α是急性髓细胞白血病细胞中信号传导和microRNA表达的调节剂
3. Camellia euphlebia protects against corticosterone-induced apoptosis in differentiated PC12 cells by regulating the mitochondrial apoptotic pathway and PKA/CREB/BDNF signaling pathway [J] . He Dongye, Wang Ning, Sai Xuan, Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research . 2019,第期

机译：通过调节线粒体凋亡途径和PKA / CREB / BDNF信号通路，山茶花eUphlebia通过调节分化的PC12细胞中的皮质酮诱导的细胞凋亡
4. Protein Interaction Partners of Protein Phosphatase 2A Catalytic Subunit in Rat β-Islet cells Using Quantitative Mass Spectrometry [C] . Divyasri Damacharla, Khadija Syeda, Xiangmin Zhang, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：使用定量质谱法在大鼠β-胰岛细胞中蛋白质磷酸酶2A催化亚基的蛋白质相互作用伴侣
5. Does long-term protein phosphatase 2A inhibition in mice dysregulate peripheral glucose homeostasis, lower hepatic glycogen content, and impair insulin-mediated signal transduction in the liver? [D] . Lee, Juyeon. 2016

机译：小鼠长期蛋白质磷酸酶2A抑制作用是否会异常调节外周葡萄糖稳态，降低肝糖原含量并损害肝脏中胰岛素介导的信号转导？
6. The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells [O] . Peter P. Ruvolo, Vivian R. Ruvolo, Rodrigo Jacamo, -1

机译：磷酸酶2A调节亚基B55α是急性髓细胞白血病细胞中信号传导和microRNA表达的调节剂
7. Senkyunolide A protects neural cells against corticosterone-induced apoptosis by modulating protein phosphatase 2A and alpha;-synuclein signaling [O] . Shenglan Gong, Jin Zhang, Zhouke Guo, 2018

机译：SenkyunoLide A通过调节蛋白质磷酸酶2a和α-突触核蛋白信号传导来保护神经细胞免受皮质酮诱导的细胞凋亡
8. Protein Phosphatase 2A Signaling in Human Prostate Cancer. [R] . Singh, A. 2014

机译：蛋白磷酸酶2a信号在人类前列腺癌。

Senkyunolide A protects neural cells against corticosterone-induced apoptosis by modulating protein phosphatase 2A and α-synuclein signaling

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