Background: Bisphenol A (BPA) is used to produce polycarbonate plastics and epoxy resins that are widely used in everyday products, such as food and beverage containers, toys, and medical devices. Human biomonitoring studies have suggested that a large proportion of the population may be exposed to BPA. Recent epidemiological studies have reported correlations between increased urinary BPA concentrations and cardiovascular disease, yet the direct effects of BPA on the heart are unknown.Objectives: The goal of our study was to measure the effect of BPA (0.1–100 μM) on cardiac impulse propagation ex vivo using excised whole hearts from adult female rats.Methods: We measured atrial and ventricular activation times during sinus and paced rhythms using epicardial electrodes and optical mapping of transmembrane potential in excised rat hearts exposed to BPA via perfusate media. Atrioventricular activation intervals and epicardial conduction velocities were computed using recorded activation times.Results: Cardiac BPA exposure resulted in prolonged PR segment and decreased epicardial conduction velocity (0.1–100 μM BPA), prolonged action potential duration (1–100 μM BPA), and delayed atrioventricular conduction (10–100 μM BPA). These effects were observed after acute exposure (≤ 15 min), underscoring the potential detrimental effects of continuous BPA exposure. The highest BPA concentration used (100 μM) resulted in prolonged QRS intervals and dropped ventricular beats, and eventually resulted in complete heart block.Conclusions: Our results show that acute BPA exposure slowed electrical conduction in excised hearts from female rats. These findings emphasize the importance of examining BPA’s effect on heart electrophysiology and determining whether chronic in vivo exposure can cause or exacerbate conduction abnormalities in patients with preexisting heart conditions and in other high-risk populations.Citation: Posnack NG, Jaimes R III, Asfour H, Swift LM, Wengrowski AM, Sarvazyan N, Kay MW. 2014. Bisphenol A exposure and cardiac electrical conduction in excised rat hearts. Environ Health Perspect 122:384–390;
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机译：背景：双酚A（BPA）用于生产聚碳酸酯塑料和环氧树脂，广泛用于日常产品，例如食品和饮料容器，玩具和医疗设备。人类生物监测研究表明，很大一部分人口可能接触过BPA。最近的流行病学研究报告了尿中BPA浓度升高与心血管疾病之间的相关性，但BPA对心脏的直接影响尚不清楚。目的：我们的研究目标是测量BPA（0.1–100μM）对心脏冲动的影响方法：我们使用心外膜电极和通过灌注介质暴露于BPA的被切除大鼠心脏中跨膜电位的光学定位，测量了窦性心律和节律性心律时心房和心室的激活时间。使用记录的激活时间计算房室激活间隔和心外膜传导速度。结果：心脏BPA暴露导致PR段延长，心外膜传导速度（0.1–100μMBPA）降低，动作电位持续时间（1–100μMBPA）延长，以及房室传导延迟（10-100μMBPA）。急性暴露（≤15分钟）后观察到这些影响，强调了连续BPA暴露的潜在有害作用。使用的最高BPA浓度（100μM）导致QRS间隔延长和心室搏动下降，并最终导致完全的心脏传导阻滞。结论：我们的结果表明，急性BPA暴露减慢了雌性大鼠切除心脏的电传导。这些发现强调了检查BPA对心脏电生理的影响以及确定慢性体内暴露是否会导致或加剧患有心脏病的患者以及其他高危人群中传导异常的重要性。引用文献：Posnack NG，Jaimes R III，Asfour H ，斯威夫特LM，Wengrowski AM，Sarvazyan N，Kay MW。 2014。切除大鼠心脏中的双酚A暴露和心脏电传导。环境健康展望122：384–390;
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