Experimental approach to the determination of pulmonary carcinogenic influences of shale oil effluents.

摘要

Oil derived from oil shale deposits is known to contain many organic complexes. The formation of carcinogenic hydrocarbons is temperature-dependent and is associated with retorting of the oil. Furthermore, oil shale is a rich source of inorganic elements such as the metals. Biological studies have demonstrated that concentrated extract of tars from combustion of shale oil are carcingenic to the skin of mice. The purpose of the current project is to evaluate the potential carcinogenic hazard from inhalation of retort and combustion effluents for man. These studies will be carried out in pathogen-free rats by intratracheal instillation with and without added factors such supplemental particles and known carcinogens as interactants.