Curated Model Development Using NEUROiD: A Web-Based NEUROmotor Integration and Design Platform

摘要

Decades of research on neuromotor circuits and systems has provided valuable information on neuronal control of movement. Computational models of several elements of the neuromotor system have been developed at various scales, from sub-cellular to system. While several small models abound, their structured integration is the key to building larger and more biologically realistic models which can predict the behavior of the system in different scenarios. This effort calls for integration of elements across neuroscience and musculoskeletal biomechanics. There is also a need for development of methods and tools for structured integration that yield larger in silico models demonstrating a set of desired system responses. We take a small step in this direction with the NEUROmotor integration and Design (NEUROiD) platform. NEUROiD helps integrate results from motor systems anatomy, physiology, and biomechanics into an integrated neuromotor system model. Simulation and visualization of the model across multiple scales is supported. Standard electrophysiological operations such as slicing, current injection, recording of membrane potential, and local field potential are part of NEUROiD. The platform allows traceability of model parameters to primary literature. We illustrate the power and utility of NEUROiD by building a simple ankle model and its controlling neural circuitry by curating a set of published components. NEUROiD allows researchers to utilize remote high-performance computers for simulation, while controlling the model using a web browser.