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Chapter 12: Decompressive Craniectomy: Long Term Outcome and Ethical Considerations

机译:第十二章:减压颅骨切除术:长期结果和伦理考虑

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摘要

Decompressive craniectomy (DC) for the treatment of severe traumatic brain injury (TBI) has been established to decrease mortality. Despite the conclusion of the two largest randomized clinical trials associating the effectiveness of decompressive craniectomy vs. medical management for patients with traumatic brain injury (TBI), there is still clinical equipoise concerning the usefulness of DC in the management of refractory intracranial hypertension. Primary outcome data from these studies reveal either potential harm or that decreased mortality only leads to an upsurge in survivors with severe neurologic incapacity. In this chapter, we seek to review the results of the most recent clinical trials, highlight the prevailing controversies, and offer potential solutions to address this dilemma.
机译:已经建立了减压颅骨切除术(DC)来治疗严重的颅脑外伤(TBI),以降低死亡率。尽管有两项最大的随机临床试验得出结论,将减压颅骨切除术与药物治疗对脑外伤(TBI)的有效性相关联,但是关于DC在治疗难治性颅内高压中的作用仍然存在临床平衡。这些研究的主要结局数据显示出潜在的危害或死亡率降低仅导致严重神经功能丧失的幸存者数量激增。在本章中,我们试图回顾最新的临床试验结果,强调当前存在的争议,并提供解决此难题的潜在解决方案。

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