Meta-populational demes constitute a reservoir for large MHC allele diversity in wild house mice (Mus musculus)

摘要

BackgroundThe MHC class I and II loci mediate the adaptive immune response and belong to the most polymorphic loci in vertebrate genomes. In fact, the number of different alleles in a given species is often so large that it remains a challenge to provide an evolutionary model that can fully account for this.