Candida glabrata complex from patients with healthcare-associated infections in Mansoura University Hospitals Egypt: distribution antifungal susceptibility and effect of fluconazole and polymyxin B combination

摘要

IntroductionCandida glabrata complex is composed of three cryptic species, Candida glabrata sensu stricto, C. bracarensis and C. nivariensis. Its reduced susceptibility to fluconazole is responsible for treatment failure of its infections. Combination therapy is recommended to treat these resistant strains. This study assessed the distribution of C. glabrata complex collected from patients in Mansoura University Hospitals and their antifungal susceptibility, with evaluation of fluconazole and polymyxin B combination against them.