Survey of the Effect of Streptokinase on Ventricular Repolarization by Examining the QT Dispersion in Patients With Acute Myocardial Infraction in Seyed-Al-Shohada Hospital Urmia

摘要

Cardiovascular events are the most common cause of morbidity and mortality throughout the world and myocardial infarction is the most common cause of these accidents. Myocardial infarction impairs the mechanical and electrical activity of the heart that these disorders predispose the patient to cardiac arrhythmias including ventricular tachycardia. QT dispersion is an important parameter to evaluate the heterogeneity of ventricular repolarization that minimal and the maximum interval is QTc in 12-lead EKG. In this study, 200 patients with the diagnosis of acute myocardial infraction with ST-segment elevation were hospitalized and treated with streptokinase. Patient records were extracted from the medical records department. EKG was studied before receiving streptokinase, an hour after receiving streptokinase and 4 days later for calculating and comparing QTd. It was concluded that QTd mean in EKG one hour after receiving streptokinase is decreased compared to pre-operation but this decline is not statistically significant. QTd mean in EKG day 4 after MI is slightly increased compared to the baseline, which is not statistically significant.