Anti-tumor activity and signaling events triggered by the isothiocyanates sulforaphane and phenethyl isothiocyanate in multiple myeloma

摘要

BackgroundIsothiocyanates, a family of phytochemicals found in cruciferous vegetables, have cytotoxic effects against several types of tumor cells. Multiple myeloma is a fatal disease characterized by clonal proliferation of plasma cells in the bone marrow. The growing body of preclinical information on the anti-cancer activity of isothiocyanates led us to investigate their anti-myeloma properties.