Sequential Synthesis Olfactory Properties and BiologicalActivity of Quinoxaline Derivatives

摘要

A simple, practical, and rapid access to quinoxalin-2-ones >1, 1,2,3,4-tetrahydroquinoxalines >2, quinoxalines >3, and quinoxalin-2(1H)-ones >4 has been achieved, based on the copper-catalyzed quinoxalinone formation of 2-haloanilines and amino acids followed by their reduction and oxidation. The olfactory properties and lipid accumulation inhibitory activity in cultured hepatocytes of the quinoxaline derivatives were also evaluated.