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Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis

机译：利用未受约束的靶组织暴露作为基于治疗的基本理论的一部分的药代动力学和药效学用于治疗2期人类非洲锥虫病的苯并x硼烷铅优化。

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期刊名称 Cambridge Open Access
作者
STEPHEN WRING; ERIC GAUKEL; BAKELA NARE; ROBERT JACOBS; BETH BEAUDET; TANA BOWLING; LUKE MERCER; CYRUS BACCHI; NIGEL YARLETT; RYAN RANDOLPH; ROBIN PARHAM; CINDY REWERTS; JACOB PLATNER; ROBERT DON;
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年(卷),期 -1(141),1
年度 -1
页码 104–118
总页数 15
原文格式 PDF
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外文文献

1. Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis [J] . WringS., GaukelE., NareB., Parasitology . 2014,第1期

机译：药物动力学和药效学利用未受限制的靶组织暴露作为基于方位的基本原理来优化苯并恶硼酸铅在治疗2期人类非洲锥虫病中的应用
2. SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis [J] . Robert T. Jacobs, Bakela Nare, Stephen A. Wring, PLOS Neglected Tropical Diseases . 2011,第6期

机译：SCYX-7158，一种口服活性的苯并沙硼烷，用于治疗2期人类非洲锥虫病
3. Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis [J] . Brand Stephen, Norcross Neil R., Thompson Stephen, Journal of Medicinal Chemistry . 2014,第23期

机译：布鲁氏锥虫N-肉豆蔻酰基转移酶抑制剂的吡唑磺酰胺系列的铅优化：CNS渗透性化合物的鉴定和评估作为2期人类非洲锥虫病的潜在治疗方法
4. SCYX-7158 an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis [O] . Robert T. Jacobs, Bakela Nare, Stephen A. Wring, 2011

机译：SCYX-7158一种口服活性的苯并沙硼酸酯用于治疗2期人类非洲锥虫病
5. Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis [O] . STEPHEN WRING, ERIC GAUKEL, BAKELA NARE, 2013

机译：药代动力学和药效学利用未结合目标组织暴露作为基于处置的基本理由的一部分，用于苯并氧基阶段的阶段2人非洲锥虫病中的苯并氧基

Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis

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