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Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration

机译：组蛋白脱乙酰基酶4的减少通过释放组蛋白脱乙酰基酶4对矮子相关转录因子2的抑制并增加骨关节炎相关基因而与人骨关节炎软骨变性相关：人骨关节炎软骨退化的新机制

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IntroductionTo investigate if decreased histone deacetylase 4 (HDAC4) is associated with human osteoarthritis (OA) cartilage degeneration by releasing HDAC4 inhibition of runt-related transcription factor-2 (Runx2) resulting in increase of OA cartilage degeneration-related genes.

机译：简介为了研究降低的组蛋白脱乙酰基酶4（HDAC4）是否与人类骨关节炎（OA）软骨变性有关，方法是释放HDAC4对矮子相关转录因子2（Runx2）的抑制作用，从而导致OA软骨变性相关基因的增加。

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期刊名称 Arthritis Research
作者
Kun Cao; Lei Wei; Zhiqiang Zhang; Li Guo; Congming Zhang; Yongping Li; Changqi Sun; Xiaojuan Sun; Shaowei Wang; Pengcui Li; Xiaochun Wei;
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作者单位

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年(卷),期 2014(16),6
年度 2014
页码 491
总页数 13
原文格式 PDF
正文语种
中图分类外科学;
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专利

1. Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration [J] . Cao Kun, Wei Lei, Zhang Zhiqiang, Arthritis research & therapy. . 2014,第6期

机译：组蛋白脱乙酰基酶4的减少通过释放组蛋白脱乙酰基酶4对矮子相关转录因子2的抑制并增加骨关节炎相关基因而与人骨关节炎软骨变性相关：人骨关节炎软骨退化的新机制
2. Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration [J] . Kun Cao, Lei Wei, Zhiqiang Zhang, Arthritis Research . 2014,第6期

机译：组蛋白脱乙酰基酶4的减少通过释放组蛋白脱乙酰基酶4对矮子相关转录因子2的抑制并增加骨关节炎相关基因而与人骨关节炎软骨变性相关：人骨关节炎软骨退化的新机制
3. NAD-DEPENDENT DEACETYLASE SIRTUIN-1 MEDIATES THE MECHANICAL STRESS-INDUCED DEGENERATION OF ARTICULAR CARTILAGE IN OSTEOARTHRITIS: MECHANICAL STRESS STIMULATES THE EXPRESSION OF OSTEOGENIC TRANSCRIPTION FACTOR RUNX2 VIA THE SRITUIN-1 ACTIVATION IN CHONDROCYTES [J] . Osteoarthritis and cartilage . 2020,第Suppla1期

机译：NAD依赖性脱乙酰酶Sirtuin-1介导骨关节炎的机械应力诱导的关节软骨退化：机械应力刺激通过软骨细胞中的Srituin-1活化刺激成骨转录因子Runx2的表达
4. Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis [C] . Meina Wang, Jie Shen, Hongting Jin, Conference on Skeletal Biology and Medicine . 2011

机译：理解骨关节炎内软骨变性分子机制的最新进展
5. Molecular mechanisms of articular cartilage degeneration in experimental knee osteoarthritis [D] . Appleton, C. Thomas G. 2007

机译：实验性膝骨关节炎的关节软骨退变的分子机制
6. Osteoarthritis-Related Degeneration Alters the Biomechanical Properties of Human Menisci Before the Articular Cartilage [O] . Andreas M. Seitz, Felix Osthaus, Jonas Schwer, 2021

机译：骨关节炎相关的变性改变了关节软骨前人肿瘤的生物力学特性
7. Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration [O] . Kun Cao, Lei Wei, Zhiqiang Zhang, 2014

机译：组蛋白脱乙酰基酶4的减少通过释放组蛋白脱乙酰基酶4对矮子相关转录因子2的抑制并增加骨关节炎相关基因而与人骨关节炎软骨变性相关：人骨关节炎软骨退化的新机制

Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration

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