A new cellular growth factor termed augmenter of liver regeneration (ALR) has been crystallized, ALR has been shown to have a proliferative effect on liver cells while at the same time producing an immunosuppressive effect on liver-resident natural killer cells and liver-resident mononuclear leukocytes. In addition, ALR appears to play an important role in the synthesis and stabilization of mitochondrial gene transcripts in, actively regenerating cells. ALR crystals diffract to beyond 2Å resolution and belong to space group P21212, with a = 125.1, b = 108.1 and c = 38.5Å. Based on four molecules per asymmetric unit, the Matthews coefficient is calculated to be 2.16Å3Da−1 which corresponds to a solvent content of 43 %.
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