Aim: To investigate the relation between change in systemic blood pressures an d change in intraocular pressure. Methods: This was a population based study of people 43-86 years old living in Beaver Dam, Wisconsin. Measurements at baselin e (1988-90) and 5 year follow up of systemic blood pressures, intraocular press ures, and history of use of blood pressure medications. Results: Intraocular pre ssures were significantly correlated with systolic and diastolic blood pressures at both baseline and follow up. There were significant direct correlations betw een changes in systemic blood pressures and changes in intraocular pressure. The re was a 0.21 (95%CI: 0.16 to 0.27) mm Hg increase in IOP for a 10 mm Hg increa se in systolic and 0.43 (0.35 to 0.52) mm Hg increase in IOP for a 10 mm Hg incr ease in diastolic blood pressure. Further adjustment for diabetes and medication use did not alter these associations. Decreased systolic or diastolic blood pre ssures of more than 10 mm Hg over 5 years were significantly associated with dec reased IOP. Conclusions: Reduced systemic blood pressure is associated with redu ced intraocular pressure. T5his finding should be evaluated in other studies, es pecially with respect to the possibility of resultant decreased risk of open ang le glaucoma.
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