The purpose of this study was to determine whether there is a difference in body composition and the factors that are associated with fat mass in the large-for -gestational -age infants of women with gestational diabetes mellitus compared with the large -for -gestational -age infants of women with normal glucose tolerance levels.Large for gestational age was defined as weigh t >90th percentile for gestational age,race,and sex on the basis of our popula-tion’s normative data.Anthropometric me asurements and /or total body electrical conductivity estimated body com-position that included fat mass,percent body fat,and lean body mass were obtained.Multiple stepwise regression was used to determine factors correlating with fat mass.Fifty cases of women with gestational diab etes mellitus and 52cases of women with normal glucose to lerance levels were evaluated.Infants of mothers with g estational diabetes mellitus had increased fat mass(662vs 563g;P =.02)and percent body fat(16.2%vs 13.5%;P =.002)but decreased lean body mass(3400vs 3557g;P =.0009),as compared with infants of mothers w ith normal glucose tolerance levels,despite similar b irth weights.Stepwise regression on all 102women showed ge stational age and a diagnosis of gestational diabetes m ellitus correlated with fat mass(r2 =0.11;P =.001).For gestational dia-betesmellitus alone,both gestatio nal age and fasting value of the oral glucose tolerance test co rrelated with fatmass and percent body fat(r 2 =0.33P=.0009and r 2 =0.26P =.005,respectively).Large -for -gestational -age infants of mothers with gestational diabetes mellitus have increased fat mass and decreased lean body mass compared with infants of mothers with normal g lucose tolerance lev-els.In gestational diabetes mellit us,gestational age and fasting value of the oral glucose tolerance test correlated best with fat mass.
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