目的：探讨进展期胃癌切除术后早期5-氟尿嘧啶（5-Fu）腹腔内化疗可行性。方法256例进展期胃癌术后患者分为早期腹腔化疗（治疗组）和早期静脉化疗（对照组）各128例，治疗组胃癌切除术后第3～5天给予5-Fu腹腔注入，对照组胃癌切除术后第3-5天给予5-Fu静脉化疗，并对比治疗效果。结果腹腔化疗组无明显毒副反应，术后1a、2a、3a生存率分别为88.3%、72.7%和51.6%；显著高于对照组68.8%、57.0%和37.5%（P＜0.01与＜0.05）。结论5-Fu胃癌术后早期腹腔化疗是安全可行的，较静脉化疗毒副反应小，对侵及或侵出浆膜的进展期胃癌有着防止复发的重要价值。%ObjectiveTo investigate the early 5- fl uorouracil in advanced gastric cancer after resection (5-Fu) intraperitoneal chemotherapy feasibility.Methods 256 cases of advanced gastric cancer patients were divided into early intraperitoneal chemotherapy (treatment group) and early intravenous chemotherapy (control group) 128 cases, the treatment group after resection of gastric carcinoma 3-5 with 5-Fu intraperitoneal injection, the control of intravenous 5-Fu chemotherapy given day 3~5 group after resection of gastric carcinoma, and the ratio of treatment effect.Results intraperitoneal chemotherapy group had no obvious adverse reactions, postoperative 1a, 2a, 3A survival rates were 88.3%, 72.7% and 51.6%; was signifi cantly higher than that in control group 68.8%, 57% and 37.5% (P < 0.01 and < 0.05).Conclusion 5-Fu early postoperative intraperitoneal chemotherapy is safe and feasible, with adverse reaction of intravenous chemotherapy, or invading serosa of invasion of advanced gastric cancer has important value to prevent recurrence.
展开▼
