益心解毒颗粒对动物心律失常的保护作用

摘要

目的:观察益心解毒颗粒对由CaCl2和乌头碱诱发动物心律失常的保护作用.方法:采用大鼠末次用药60min后,舌下注射CaCl2和乌头碱诱发大鼠心律失常,观察大鼠心电图变化及心律失常情况.结果:益心解毒颗粒3g/kg可明显提高CaCl2心律失常大鼠的存活率;益心解毒颗粒1.5～6.0g/kg可推迟乌头碱致大鼠心律失常的发生时间、缩短心律失常持续时间.结论:益心解毒颗粒对动物心律失常有明显保护作用.%Objectives:The study is to investigate the effect of Yixin Jiedu Granule on animal arrhythmia induced by CaCl2 and Aconitine.Methods:Sixty minutes later of the last medication, rats were injected sublingually with the CaCl2 or Aconitine, and assessed for any change or arrhythmia on ECG.Results:Yinxin Jiedu Granule at the dosage of 3g/kg significantly raised the survival rate of rats of arrhythmia induced by CaCl2; at the dosage of 1.5-6.0g/kg it postponed the occurrence of arrhythmia induced by Aconitine, and shortened the duration of arrhythmia.Conclusion:Yixin Jiedu Granule has significant protective effect on arrhythmia of lab animals.