艾灸温通温补效应的作用机制及其规律研究

摘要

Based on the research of principles and mechanism of warm-unblock and warm-tonic effects induced by moxibustion ,one branch of the moxibustion project supported by the National Key Basic Research and Development Program (973 Program),focused on the hypothesis that burning moxa could generate warm-unblock and warm-tonic effects by warm stimulation,taken epigastralgia with spleen yang deficiency syndrome as the target disease ,followed its pathogenesis that middle Jiao fail to transportation due to the deficien-cy of spleen yang,considered the corresponding treatment principle of tonifying spleen and stomach by warm ,unblock and tonification,the study aims to explore the mechanism of warm-unblock and warm-tonic effects,the relation between these two effects and the characteris-tics of effects rules.The preliminary results showed that the mechanism of warm-unblock and warm-tonic effects could be modulation the neural-endocrine-immune pathway and also the function of Zangfu organs ,and promotion the circulation of Qi and blood by activating the related acupoints.They also indicated that the relations of effects would be presented as following:warm-effect would promote unblock-effect and generate tonic-effect;unblock-effect would enhance tonic-effect,and vice versa.Moreover,they pointed out the characteristics of effect principles might be unblock-and tonic-effect features,particularity,conditionality,extent,diversity and sustainability.%本研究以灸法973项目的课题“艾灸的温通温补效应规律及其原理研究”为依托，围绕“艾灸的温热刺激能产生温通温补效应”这一假说，以脾胃虚寒型胃脘痛为疾病载体，遵循其“脾胃虚寒、中阳不运”的病机特点，拟定其“健脾益胃、温通补虚”的治疗原则，探讨艾灸温通与温补效应的作用机制，两种效应之间的关系以及效应规律的特点。研究结论：证实艾灸温通温补效应的作用机制为艾灸激活穴位（局部始动），推动气血运行，调节神经-内分泌-免疫网络（调节通路），调节脏腑功能（效应器官响应）。阐明艾灸温通、温补效应之间的关系为“以温促通、以温达补，以通促补、以补促通，通中有补、补中有通、通补互用”。初步揭示其效应规律的特点是通补性、特殊性、条件性、程度性、差异性和持续性。