药性理论指导的附子配伍减毒试验研究

摘要

目的：以附子为研究对象，试验研究基于药性理论的附子配伍减毒的科学性，以探讨附子配伍减毒的新途径。方法：对以寒制热、以甘缓毒、以柔克刚、调正抑毒等四种附子配伍减毒理论进行验证性的毒理学试验，在试验中采用急性毒性和心脏毒性相结合的试验方法。结果：附子配伍寒性药物具有配伍减毒作用，和其他三种配伍减毒相比较，以寒制热的配伍减毒作用最强。结论：以药性理论为指导的配伍减毒可以使有毒中药配伍减毒一种新的思路和方法。%Objective:In accordance with the theory of medicinal nature , we explored new ways of reducing toxicity of Fuzing by combi-ning it with other medicinal herbs .Methods:By conducting toxicological experiments ( acute toxicity in combination with cardiac toxici-ty), we tested four combination theories , i.e.using cold medicinal to inhibit hot medicinal , using sweet medicinal to relieve toxicity , u-sing soft medicinal to curb tough medicinal , modifying toxicity.Results:Compared with combining with medicinal of sweet , or soft, or modifying nature, the combination with cold medicinal proved to be most significant at reducing Fuzi ’ toxicity.Conclusion:The theory of medicinal nature provides a new thinking and method to reduce Chinese medicine ’s toxicity.