目的：通过现代文献研究，分析中医周期疗法治疗多囊卵巢综合征（PCOS）的用药特点，为提高 PCOS 的临床疗效提供依据。方法：对2000—2014年的相关临床研究文献进行检索，应用 Excel 软件，对周期治疗 PCOS 中所用中医复方及其药物建立数据库，运用 SPSS 对数据进行处理，使用复杂网络挖掘中医周期疗法中治疗 PCOS 的核心药物，分析其用药特点。结果：1）符合纳入标准的文献有51篇，其中41篇分4期治疗，10篇分3期治疗，共涉及药物151味，出现频率≥2％有当归、菟丝子、熟地黄、山药、香附、淫羊藿、川芎、山茱萸、丹参、枸杞子、茯苓和苍术。2）分期治疗常用配伍组合的药物（关联频度≥20％）依次为：经后期：当归、菟丝子、熟地黄、山药、淫羊藿、女贞子、枸杞子、山茱萸、香附、何首乌；经间期：当归、菟丝子、熟地黄、丹参、红花、山药、山茱萸、桃仁、川芎、赤芍、白芍、茯苓、香附、皂角刺、淫羊藿；经前期：当归、菟丝子、熟地黄、山药、淫羊藿、枸杞子、肉苁蓉、山茱萸、川断、何首乌、杜仲、香附；行经期：当归、赤芍、益母草、泽兰、香附、丹参、川芎、红花、桃仁、熟地黄。结论：通过复杂网络分析所获得的临床报道所用中医周期治疗 PCOS 的用药规律，体现了该病病理因素主要是（阳）虚、血瘀和痰湿；病位主要肾、肝、脾。分期治疗治法分别为：经后期以补肝肾，滋阴养血，理气健脾为主；经间期以补肝肾，理气活血为主；经前期以补肾升阳、健脾理气为主；行经期活血滋阴为主，可为进一步指导临床用药提供一定的指导。%Objective:To analysis the rule of prescription for PCOS treated by TCMperiodic therapy,and to provide the basis for the improvement of clinical curative effect by analyzing clinical literature.Methods:The authors searched the clinical literature of PCOS,built up a literature data-base by Excel software,processed by SPSS and ana1yzed by Pajek.Results:(1)51 articles met the inclusion criteria,among which 41 were divided treatment into 4 periods,and another 10 articles divided treatment into 3 peri-ods.The articles all-together included to 151 Traditional Chinese Medicine herbs,among which Chinese angelica,dodder,pre-pared rehmannia root,Chinese yam,Rhizoma Cyperi,epimedium,chuanxiong rhizome,dogwood,Salvia miltiorrhiza,wolfberry fruit,Poria and Rhizoma Atractylodis appeared with a greater percentage than or equal to 2%.(2)The following were the combi-nation of herbs that were commonly used for the treatment of PCOS (their association frequency were greater than or equal to 20%).The follicular phase:dodder,prepared rehmannia root,Chinese angelica,Chinese yam,epimedium,glossy privet fruit, wolfberry fruit,dogwood,rhizoma cyperi,radix polygoni multiflori;Ovulation:dodder,prepared rehmannia root,angelica,saf-flower,danshen,Chinese yam,cornus,peach seed,chuanxiong,radix paeoniae rubra,radix paeoniae alba,poria,rhizoma cy-peri,spina gleditsiae,epimedium;Luteal phase:dodder,prepared rehmannia root,Chinese angelica,Chinese yam,wolfberry fruit,epimedium,cistanche,dogwood,himalayan teasel root,eucommia,rhizoma cyperi,radix polygoni multiflori;Menstrual pe-riod:angelica,radix paeoniae rubra,radix salviae miltiorrhizae,rhizoma cyperi,motherwort herb,herba lycopi,chuanxiong,saf-flower,peach seed,radix rehmanniae preparata.Conclusion:Analyzing the prescription rules for PCOS treatment with TCMperi-odic therapy showed that the pathological factors were (Yang)deficiency,blood stasis and phlegme;the location of disease were kidney,liver,spleen;the main rules of treatment in follicular phase period were reinforcing liver and kidney,nourishing yin and blood,and regulating qi-flowing for strengthening spleen;the mainly rules of treatment in ovulation were reinforcing liver and kid-ney,nourishing qi and activating blood ;the mainly rules of premenstrual phase were rising the kidney yang,and regulating qi-flowing for strengthening spleen;In menstrual period the rules were mainly activating blood and nourishing Yin.The results can provide some guidance for clinical practice.
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