目的：探讨复方苦参注射液联合伊班膦酸钠治疗非小细胞肺癌骨转移癌疼痛的临床观察。方法：选取宜昌市中心人民医院2010年3月至2012年3月收治的非小细胞肺癌骨转移患者98例，根据其治疗方式的不同，分为对照组和治疗组。对照组患者采用伊班膦酸钠进行治疗，治疗组患者采用复方苦参注射液联合伊班膦酸钠进行治疗，比较2组患者的近期疗效、疼痛缓解、KPS评分改善情况。结果：患者近期疗效比较结果显示，治疗组患者部分缓解的例数（百分比）及总有效率要明显优于对照组，且差异有统计学意义（P＜0.05）。治疗组Karnofsky评分改善的例数（百分比）要明显多余对照组，且差异有统计学意义（P＜0.05）。疼痛缓解情况比较分析显示，治疗组患者完全缓解例（百分比）及总的缓解率要明显优于对照组，且差异有统计学意义（P＜0.05）。2组患者不良反应发生情况差异无统计学意义（P＞0.05）。结论：复方苦参注射液联合伊班膦酸钠对非小细胞肺癌骨转移癌疼痛具有明显的作用，能够有效的减轻患者的疼痛，值得在临床上推广应用。%Objective:To investigate the effect of matrine injection combined with ibandronate clinical observation on treatment of non small cell lung cancer pain of bone metastasis.Methods:98 patients with non small cell lung cancer bone metastasis were re-cruited from 201 0 March to 201 2 March.According to their different ways of treatment,they were divided into control group and ob-servation group.The control group was treated with ibandronate treatment,the observation group were treated by compound matrine injection combined with ibandronate treatment.Efficacy,remission,and KPS score improvement were compared.Results:The near future curative effect in the results show that the partial remission cases (%)and the total effective rate of the observation group was obviously superior to the control group,and the difference was statistically significant (P<0.05 ).Karnofsky score improve-ment cases (%)of the observation group is higher than that of the control group,and the difference was statistically significant (P<0.05 ).Pain relief comparative analysis showed that complete remission cases (%)and the total remission rate of the observa-tion group was significantly superior to the control group,and the difference was statistically significant (P<0.05 ).The incidence of adverse reactions had no significant difference between the two groups (P>0.05 ).Conclusion:Compound matrine injection combined with ibandronate is significant in treating cancer pain in non small cell lung cancer bone,and can effectively reduce the pain of patients,thus is worthy of clinical application.
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