系统药理学原理、方法及在中医药中的应用

摘要

目的：建立科学有效的现代中药研究体系，是中医药现代化进程中亟待解决的关键问题之一，然而目前从系统和整体水平研究中药的理论和方法均不成熟。方法：本文将综述当前系统药理学的最新进展，阐明如何整合药效学、药动学以及基因、蛋白、药物网络分析等技术，形成一个完整的可供中药药理学、药效学预测和验证的技术体系。结果：重点从中药基础理论、复方解析、注射液的研究、老方优化和新药开发方面介绍系统药理学在中医药中的应用。结论：本文提出的系统药理学研究体系为中药的现代研究提供了新方法学，将有助于系统、深刻地从系统水平和分子水平揭示中药和机体的相互作用机制，从而指导中药新药研发。%Objective:To establish a scientific and effective research system for modern Chinese medicine.However,the current theory and measurement methods of systems analysis of TCM are still in its infant state.Methods:The new advances of system pharmacology (SP),its practical application in investigating the basic theory of TCM,optimization of old formulae and the discovery of new drugs were covered in this study.Results:Drug pharmacokinetics,efficacy,as well as systems biology were integrated into TCMSP.Conclusion:TCMSP will be a valuable tool to help the understanding of the interaction mechanism of TCM and human body at a systematic /molecular level,so as to guide the discovery of new drugs of TCM.