针灸对细胞自噬水平的调控及其在神经退行性疾病中的作用

摘要

针灸作为传统中医的一种重要治疗方式，能够有效改善帕金森病、老年痴呆、亨廷顿氏病等神经退行性疾病的相关症状。然而，针灸作用的分子机制长期以来没有得到明确的阐释。近年来，研究发现针灸可以通过提高细胞自噬水平而促进异常积聚蛋白的清除，从而达到治疗和改善神经退行性疾病的目的。自噬是细胞清除受损细胞器及细胞内错误折叠或异常聚集蛋白质的过程，对细胞稳态的维持和细胞内物质能量的循环具有重要的作用。帕金森病、老年痴呆、亨廷顿氏病等神经退行性疾病的发生发展往往与基础水平自噬下降有关。文章综述了针灸对自噬效应的调控及其对神经退行性疾病的作用的研究进展，并对针灸在神经退行性疾病中的应用作了展望。%Acupuncture is an important treatment of traditional Chinese medicine (TCM)by mechanically stimulating specific acupoints with fine needles,which can be used for treatment of neurodegenerative diseases (e.g.Parkinson′s disease,PD;Alzhe-imer′s disease,AD;Huntington′s disease,HD).Despite its well-documented efficacy,its biological basis remains largely elu-sive.Recent studies showed that acupuncture can up-regulate the autophagy level to promote the clearance of aggregated proteins, which can relieve symptoms of neurodegenerative diseases.Autophagy is the orchestrated bulk degradation of damaged organells, misfolded or aggregated proteins.It is an intracellular recycling system that functions during basal conditions in organelle and pro-tein quality control.Loss of basal autophagy in the central nervous system is closely related to age-related neurodegeneration as seen PD,AD,HD.This paper summarized the studies on the regulating effect of acupuncture on the autophagy level in neurode-generative diseases,and provided perspective for elucidating the molecular mechanism of acupuncture.