穿心莲内酯总酯磺化物对脓毒症患者血清炎性因子的影响

摘要

Objective:To observe the effect of andrographolide total ester sulfonate on inflammatory factors in serum of patients with sepsis in different periods and to explore new methods of diagnosis and treatment of sepsis .Methods:There were 80 cases of sepsis meeting the criteria , who were hospitalized in respiratory department , respiratory ICU , emergency department , digestive de-partment, ICU and other departments of Lanzhou General Hospital of Lanzhou Military Command from December 2013 to March 2015, divided into sepsis group and severe sepsis group according to their condition .Each group were randomized into sub treat-ment group and sub control group , each 20 people, and on the day of admission , 3 days and 7 days after treatment , all patients′PCT, IL-6, CRP and HsCRP in serum were tested .Results:The Basic information and Inflammatory facotrs concentration before treatment were compared in sepsis group , severe sepsis sub treatment group and sub control group (P>0.05);it showed statisti-cal significance in the comparison of PCT , IL-6 and HsCRP level between various periods before and after the treatment ( P<0.05); in sub treatment group and sub control group , patients′CRP level before treatment was compared with that of 3 days after treatment (P<0.05), and the difference was statistically significant , while that of 3 day and 7 days after treatment in both groups were also compared (P>0.05), there was no statistical significance .IL-6, PCT and CRP concentration of severe sepsis sub treat-ment group before and after treatment 3 days were compared ( P<0.05 ) , showing no statistical significance when HsCRP in the sub control group and sub treatment group of various period was compared ( P>0.05 ) .Conclusion:Andrographolide total ester sulfonate had great effect on reducing inflammatory factors concentration like IL -6, HsCRP, PCT and CRP in sepsis and severe sepsis patients of early stage , thun it could be used as treatment of sepsis theoretically .%目的：观察穿心莲内酯总酯磺化物对脓毒症患者血清中不同时段炎性因子的影响，为临床脓毒症的诊治探讨新思路。方法：将符合纳入标准的2013年12月至2015年3月入住兰州军区兰州总医院呼吸科、呼吸ICU、急诊科、消化科、ICU等科室的脓毒症患者80例，按病情程度分为脓毒症组和严重脓毒症组，各组按就诊先后顺序随机分为治疗亚组和对照亚组，每组20例，并于入院当天、治疗后第3天、7天测定各组患者血清中PCT、IL-6、CRP、HsCRP的浓度。结果：脓毒症、严重脓毒症中治疗亚组和对照亚组基本资料及治疗前炎性因子浓度相互比较（ P＞0.05），脓毒症治疗亚组中IL-6、HsCRP、PCT水平在治疗前后各时间段分别进行比较差异有统计学意义（ P＜0.05），治疗亚组和对照亚组患者CRP水平在治疗前与治疗后第3天比较差异有统计学意义（P＜0.05），2组患者治疗后第3天与第7天分别比较，差异无统计学意义（P＞0.05）。严重脓毒症治疗亚组治疗前和治疗后第3天IL-6、PCT、CRP浓度比较（P＜0.05），HsCRP在对照亚组和治疗亚组各时间段比较差异无统计学意义（ P＞0.05）。结论：穿心莲内酯总酯磺化物可显著降低脓毒症及严重脓毒症患者发病早期IL-6、HsCRP、PCT、CRP等炎性因子的浓度，理论上可用于脓毒症的治疗。