三参归芪合剂对冠心病心力衰竭及血浆NT-proBNP 水平的影响

摘要

Objective: To observe and evaluate the effect of Three Ginseng and Guiqi Mixture in the treatment of coronary heart disease and heart failure as well as its effect on NT-proBNP level .Methods: Total 100 patients with coronary heart disease and heart failure in our hospital from January 2013 to February 2015 were randomly divided into observation group (50 patients were treated with Three Ginseng and Guiqi Mixture on the basis of the control group ) and control group (50 patients were simply treated with conventional western medicine ) .Comparative analysis of two groups′patients on syndrome of Chinese medicine , cardiac func-tion, quality of life in Minnesota survey points , NT-proBNP levels were performed .Results:The syndrome of Chinese medicine and Cardiac function effect in observation group were better than the control group , the differences were statistically significant ( P<0.01).Minnesota survey of quality of life score of the observation groups was significantly lower than the control group , the difference was statistically significant (P<0.01);plasma NT proBNP levels of the observation group were significantly lower than those in the control group, the difference was statistically significant (P<0.01).Conclusion:Three Ginseng and Guiqi Mixture has significant effect in the treatment of patients with coronary heart disease and heart failure .It can reduce NT-proBNP level of patients and improve the quality of life of patients .%目的：观察和评估三参归芪合剂对冠心病心力衰竭患者的疗效及其对NT-proBNP水平的影响。方法：随机选取我院2013年1月至2015年2月收治的冠心病心力衰竭患者100例，按照治疗方式的不同分为治疗组和对照组各50例，对照组采用常规西药治疗，治疗组在对照组的基础上加服三参归芪合剂。对比分析2组患者中医症候疗效、心功能疗效、明尼苏达生活质量调查积分、血浆NT-proBNP水平。结果：治疗组患者的中医症候的疗效和心功能疗效明显优于对照组，差异具有统计学意义（P＜0.01）；治疗组患者明尼苏达生活质量调查积分明显低于对照组患者，差异具有统计学意义（P＜0.01）；治疗组患者血浆NT-proBNP水平明显低于对照组，差异具有统计学意义（ P＜0.01）。结论：三参归芪合剂对冠心病心力衰竭患者的疗效显著，能降低患者NT-proBNP水平，提高患者的生活质量水平。