自拟清热解毒、活血化瘀方联合华蟾素治疗湿热瘀毒型宫颈癌临床观察

摘要

Objective:To analyze the effect and safety of self-made Heat-clearing and Detoxicating , Blood-activating and Stasis-re-solving Formula combined with Cinobufotalin in damp heat and toxin type of cervical carcinoma .Methods:A total of 68 patients with damp heat and toxin type of cervical carcinoma were randomly divided into observation group and control group , with 34 cases in each groups .The patients were treated with radiation and chemotherapy and surgery .Observation group added with Heat-clear-ing and Detoxicating , Blood-activating and Stasis-resolving Formula combined with Cinobufotalin .The clinical curative effect and adverse reactions were observed between the two groups .Results:The total effective rate of the observing group was 85.2%, con-trol group 70.5%, which had no statistical significance (P>0.05).The differences between the two groups in nausea and vomi-ting, liver and kidney damage , loss of hair, neurotoxicity, and a lower incidence of adverse reactions such as electrolyte disorder were statistically significant different ( P<0.05 ) .Conclusion:Heat-clearing and Detoxicating , Blood-activating and Stasis-resol-ving Formula combined with Cinobufotalin in damp heat and toxin type of cervical carcinoma has clinical curative effect of high sat -isfaction, with less adverse reaction .%目的：分析自拟清热解毒、活血化瘀方联合华蟾素治疗湿热瘀毒型宫颈癌临床疗效及其安全性。方法：68例湿热瘀毒型患者随机分为对照组和观察组各34例，2组均采用放化疗治疗及手术治疗。观察组加用清热解毒、活血化瘀类中药联合华蟾素治疗，观察2组临床疗效及不良反应情况。结果：总有效率观察组85.2％，对照组70.5％，2组比较差异无统计学意义（ P＞0.05）.观察组恶心呕吐、肝肾损伤、脱发、神经毒性及电解质紊乱等不良反应发生率更低，与对照组比较差异具有统计学意义（ P＜0.05）。结论：清热解毒、活血化瘀类中药联合华蟾素治疗湿热瘀毒型宫颈癌临床疗效满意度高，不良反应少。