补中柴前连梅煎对支气管扩张症大鼠模型肺气管组织病理学的影响

摘要

Objective:To explore the effect of Buzhong Chaiqian Lianmei Decoctionon on histopathology of the lung and trachea of rat model with bronchiectasis .Methods:The study was to compare the different effects of Buzhong Chaiqian Lianmei Decoctionon on histopathology of tracheobronchial tissue and lung tissue in rat model with bronchiectasis which was established by intratracheal injection of pseudomonas aeruginosa liquid .Results:The scores in the ciliated columnar epithelium and glandular cell pathological of model group , treatment group and control group were not significantly different ( P>0.05 ) .The scores in intraluminal secre-tions and inflammatory cell infiltration of model group , treatment group and control group were significantly different (P<0.05). The total tracheobronchial pathological score of tracheobronchial pathological in model group compared with the control group had significant difference (P<0.05), while no significant difference showed between the treatment group and the control group (P>0.05).The scores in the bronchus invasion site , infiltration of qualitative, perivascular infiltration, interstitial pneumonia patho-logical and the total lung pathological score between the model group and the control group were significantly different (P<0.05) and there was no significantly different in the scores of the bronchioles bronchial exudate between the model group and the control group (P>0.05).The scores in the tracheal and bronchial infiltrative sites , infiltration of qualitative and vascular permeability , perivascular infiltration , interstitial pneumonia pathological and the total lung tissue pathological score between the treatment group and the control group showed not significantly different (P>0.05).Conclusion:Buzhong Chaiqian Lianmei Decoction can signif-icantly improve bronchiectasis in rats with peripheral inflammatory infiltration , perivascular inflammatory infiltration and interstitial pneumonia , and improve the tracheobronchial tissue pathology via holistic regulation .%目的：探讨补中柴前连梅煎对支气管扩张症模型大鼠气管肺组织病理学的影响。方法：以铜绿假单胞菌液注入大鼠气管内的方法建立大鼠支气管扩张症模型，以补中柴前连梅煎进行干预，比较补中柴前连梅煎对支气管扩张症模型大鼠气管支气管组织、肺脏组织病理学的影响。结果：在气管支气管组织病理评分上，模型组、治疗组与空白组在柱状纤毛上皮、腺体细胞病理评分比较差异无统计学意义（P＞0.05），模型组、治疗组与空白组在管腔内分泌物、炎性细胞浸润病理评分比较差异有统计学意义（P＜0.05），在总分上模型组与空白组比较差异有统计学意义（P＜0.05），而治疗组与空白组比较差异无统计学意义（P＞0.05）；在肺脏组织病理评分上，模型组与空白组在细支气管支气管周围浸润部位、浸润的定性、血管周围浸润、间质性肺炎病理评分及总分比较差异有统计学意义（P＜0.05），而模型组与空白组在细支气管支气管腔渗出比较差异无统计学意义（ P＜0.05）；治疗组与空白组在气管支气管周围浸润部位、浸润的定性、管腔渗、血管周围浸润、间质性肺炎病理评分及总分比较均差异无统计学意义（ P＞0.05）。结论：补中柴前连梅煎可明显改善支气管扩张症模型大鼠气管支气管周围炎性浸润、血管周围炎性浸润及间质性肺炎，其对气管支气管组织病理学改善主要表现为整体调理作用。