清热解毒汤治疗绝经期妇女牙周炎的临床效果及对龈沟液炎性反应因子的影响

摘要

Objective:To explore the clinical efficacy of Qingrejiedu decoction on periodontitis of menopausal women and the influ －ence on inflammatory factors in gingival crevicular fluid.Methods:A total of 80 cases periodontitis of menopausal women patients were selected and divided into the observation group and the control group ,according to different treatment methods ,with 40 cases in each group.The 2 groups were given periodontal basic treatment.The control group was given cefradine and metronidazole and the observation group was added with Qingrejiedu Tang on.The 2 groups were treated for 1 month continuously.The clinical efficacy of 2 groups,the improvement of periodontal clinical indexes ,the expression of inflammatory factors and other related indexes in gin－gival crevicular fluid before and after treatment were compared.Results:The total effective rate was 95.00% in the observation group,which was significantly higher than 77.50%in the control group ( P＜0.05 ).Compared with those before treatment ,the PD,SBI,CAL,PLI in 2 groups after treatment significantly decreased ,and the experiment group was significantly lower than control group ( P＜0.05 or P＜0.01 ).Compared with those before treatment ,the expression levels of IL－1β,TNF－α,RANKL in 2 groups after treatment significantly decreased ,OPG significantly increased,and the difference between the 2 groups was significant ( P＜0.05 or P＜0.01 ).Conclusion:Combined with Qingrejiedu Tang on the basis of conventional western medicine treatment can ef －fectively improve the periodontal inflammation and periodontal clinical indicators of menopausal women and promote alveolar bone repair.The clinical efficiency is better than the treatment of traditional western medicine.%目的:探讨清热解毒汤治疗绝经期妇女牙周炎的临床效果及对龈沟液炎性反应因子的影响.方法:选取2014年6月至2015年7月华北理工大学附属医院收治的绝经期牙周炎患者80例,根据治疗方法不同分为观察组和对照组,每组40例. 2组均给予牙周基础治疗,对照组给予头孢拉定和甲硝唑,观察组在此基础上增加清热解毒汤治疗,2组均连续治疗1个月.比较2组临床疗效、治疗前后牙周临床指标改善情况、患牙龈沟液中炎性反应因子及其他相关指标表达水平.结果:治疗后观察组总有效率为95.00%,显著高于对照组的77.50%( P＜0.05).与治疗前比较,治疗后2组PD、SBI、CAL、PLI均明显降低,且观察组明显低于对照组(P＜0.05或P＜0.01).与治疗前比较,治疗后2组患牙龈沟液中IL－1β、TNF－α及RANKL表达水平均明显降低,OPG均明显升高,且差异有统计学意义(P＜0.05或P＜0.01).结论:在常规西医治疗的基础上联合清热解毒汤可以有效改善绝经期妇女牙周炎性反应及牙周临床指标,促进牙槽骨组织修复,临床疗效优于单独西医治疗.