岩鹿乳康胶囊对乳腺增生大鼠血清雌孕激素的影响

摘要

Objective:To study the effects of Yanlu Rukang Capsule on estrogen and progesterone in serum of rats with hyperplasia of mammary glands.Methods:All 60 Wister rats were randomly divided into six groups : blank control group, tamoxifen group, Yanlu Rukang group , Rupixiao group, disease model group, ovariectomized group.Then, the content of estradiol (E2) and pro－gesterone (P) in serum of rats were detected by ELISA methods.Results:Compared with Rupixiao group and model group , the content of E2in blood in the Yanlu Rukang group was significantly decreased , and the content of P was significantly higher (P＜0.01); Compared with tamoxifen group , the content of E2and P in the blood in the Yanlu Rukang group did not significantly changed, and there was no statistical significance (P＞0.05).Conclusion:Yanlu Rukang capsule can significantly reduce estro－gen and elevated progesterone levels in blood.%目的:探讨岩鹿乳康胶囊对成年雌性乳腺增生大鼠血清雌激素、孕激素水平的影响.方法:选取Wister大鼠60只,将其随机分为6组:空白组、疾病模型组、去卵巢组、三苯氧胺组、乳癖消组、岩鹿乳康胶囊组.采用酶联免疫吸附试验(ELISA)检测大鼠血清中雌二醇(E2)和孕酮(P)水平.结果:与乳癖消组以及疾病模型组比较,岩鹿乳康组血液中E2的水平均显著降低(P＜0.05),P水平明显升高(P＜0.05);与三苯氧胺组比较,岩鹿乳康组血液中E2和P水平差异无统计学意义(P＞0.05).结论:岩鹿乳康胶囊能显著降低血中雌激素以及升高孕激素水平.