Toxicological advances of traditional medicine in 2020

摘要

There were many researches concerning toxicology of traditional medicine and active natural products during the past 12 months.This annual toxicology review summarized different toxic analysis methods of traditional medicine,evaluated models,toxic target organs,toxic mechanisms,popular research issues and herbs in 2020.Caenorhabditis elegans came to use for the assessment of toxicity.Omics technology such as genomics,transcriptome,metabolomics and proteomics were applied extensively.2020 toxicology research demonstrated that liver,kidney and heart were the mainly toxic target organs of traditional medicine.Their toxic mechanisms included cell apoptosis,metabolic disorder,oxidative stress,inflammatory damage,liver and renal fibrosis and even inducing carcinogenesis.In addition,the safety assessment of Aconitum carmichaeli Debx.,Tripterygium wilfordii Hook.f.and Polygonum multiflorum Thunb.as well as their detoxification methods were still hot issue.Therefore,study on the toxicity mechanism of target organs,processing and extract methods,quality control and dose control,new models and methods should be used in the prevention of traditional medicine toxicology in the future.