Metabonomics/metabolomics analysis technology and its application in quality control of traditional Chinese medicines

摘要

中药是我国传统医药的重要组成部分，然而其“安全、有效、稳定、可控”的问题一直难以解决。20世纪新兴起的代谢组学与中药的多成分、多层次、多靶点、多代谢途径的整体调节观念一致，这有利于解决中药在质量控制上的基本问题。本文系统的介绍了近几年1H-NMR代谢组学技术、LC-MS代谢组学技术和GC-MS代谢组学技术的在中药质量控制上的应用与发展，为中药及中药产品的鉴定及质量评价提供了新的参考依据。%Chinese medicines are an important part of traditional Chinese medicines, but their "safe, effective, stable and controllable"issue still remains to be solved. The rise of metabonomics in 20th century, consistent with the overall adjustment concept of multi-component, multi-level, multi-target, multi-metabolic pathways of traditional Chinese medicines, is conducive to solve basic problems in their quality control. This paper systematically describes recent application and development of 1H-NMR metabonomics techniques, LC-MS metabonomics techniques and GC-MS metabonomics techniques in the quality control of traditional Chinese medicines. It provides a new reference for Chinese medicines and the identification and quality assessment of their products.