紫杉醇联合奈达铂与氟尿嘧啶联合奈达铂同步放化疗治疗中晚期宫颈癌的疗效和不良反应

摘要

OBJECTIVE To observe the short-term curative effect ,long-term curative effect and the adverse re-action of paclitaxel combined with nedaplatin concurrent radiotherapy and fluorouracil combined with nedaplatin con -currentchemotherapyintreatmentofadvancedcervicalcancer.METHODS 66casesofpatientswithadvanced cervical cancer were collected as study cases ,they were divided into two groups according to the random double blind methods with 33 cases in each group , the control group used fluorouracil combined with nedaplatin chemotherapy , while the observation group used paclitaxel combined with nedaplatin concurrent radiotherapy , short-term curative effect,1,2,3yearsurvivalrateandadversecircumstanceoftwogroupswereobservedandcompared.RESULTS 11 cases of the observation group were complete remission ,partial remission in 14 patients,the calculation efficiency was 75.76%;while 7 cases in the control group was complete remission ,partial remission in 10 patients,the calculation efficiency was 51.52%,the effective rate of two groups had significant difference ( P<0.05 );1,2,3 year survival rate in the observation group were respectively 100%,90.91%,75.76%,and which had significantly different ( P<0.05 ) with the control group;the main side effect of two group were gastrointestinal reaction and bone marrow sup-pression ,the leukopenia ,thrombocytopenia ,anemia and nausea vomiting rate in the observation group were 39.39%, 21.21%, 15.15% and 30.30%, decreased significantly ( P <0.05 ) when compared with the control group.CONCLUSION Paclitaxel combined with nedaplatin concurrent radiotherapy has a better recent efficacy in treatment of advanced cervical carcinoma than fluorouracil combined with nedaplatin chemotherapy ,and 1,2,3 year survival rates were significantly increased , adverse reaction decreased significantly , which has a higher application value.%目的 观察紫杉醇联合奈达铂与氟尿嘧啶联合奈达铂同步放化疗治疗中晚期宫颈癌的近期疗效、远期疗效及不良反应情况. 方法 收集临床确诊的66例中晚期宫颈癌患者为研究病例,采取随机双盲法进行分组,每组各有33 例,其中对照组应用氟尿嘧啶联合奈达铂同步放化疗,观察组应用紫杉醇联合奈达铂同步放化疗,观察并比较两组的近期疗效、1、2、3 年生存率及不良反应情况. 结果 观察组中11 例完全缓解,14例部分缓解,计算有效率为75.76%;而对照组中7例完全缓解,10例部分缓解,计算有效率为51.52%,两组有效率相比较差异显著( P<0.05);观察组患者1、2、3年生存率分别为100.00%、90.91%、75.76%,与对照组患者同时间生存率比较均有显著性差异(P<0.05);两组不良反应主要表现为消化道反应和骨髓抑制,其中观察组患者白细胞减少、血小板减少、贫血及恶心呕吐的发生率分别为39.39%、21.21%、15.15%及30.30%,与对照组比较均有显著降低(P<0.05). 结论 紫杉醇联合奈达铂同步放化疗治疗中晚期宫颈癌近期疗效明显优于氟尿嘧啶联合奈达铂同步放化疗治疗,且患者1、2、3年生存率显著提高,不良反应明显降低,应用价值较高.