Metronidazole, tinidazole and ornidazole are 5-nitro-imidazole medicines used particularly for anaerobic bacteria and protozoa infections. The present paper reports that terahertz time-domain spectroscopy (THz-TDS) and Fourier transform infra-red spectroscopy (Far-FTIR) were used to measure the fingerprint spectra of metronidazole, tinidazole and ornidazole in the frequency range of 0. 9-19. 5 THz under the room temperature. In addition, THz-TDS was also used to measure the absorption spectra of pure tinidazole and tinidazole tablets from different manufactures between 0. 2 and 2. 2 THz. In parallel with the experimental study, the cross correlation analysis was applied to compare the array of correlation coefficients between pure tinidazole and different tinidazole tablets. Results show that the method is rapid, simple and accurate to identify their effective chemical compositions and stability when the FTIR and THz spectra data combine with the array of correlation coefficient. Our research provides a visual approach to the standardization and modernization of the quality control in the production and sale of such drugs.%甲硝唑、替硝唑和奥硝唑为5'-硝基咪唑类化合物,常用于抗厌氧菌和抗滴虫治疗.运用太赫兹时域光谱技术(THz-TDS)和傅里叶变换红外光谱(FTIR)技术在室温环境中测量了三种药品在0.9～19.5THz波段的光谱特性,得到其指纹谱.另外,通过探测替硝唑参照品和不同厂家、不同批次替硝唑药片在太赫兹波段的光谱信息,结合相关系数法、阵列相关系数法等信息处理技术对光谱信号进行数据挖掘；最终建立了一种能够快速、有效、系统地鉴定替硝唑片活性成分和稳定性的分析方法.研究结果为此类药品生产和销售质量的规范化和现代化提供了可视化途径.
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