肝动脉栓塞化疗和经皮乙酸消融双介入治疗巨块型肝癌的临床价值及应用研究

摘要

Objective: To study the efficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous acetic acid injection (PAI) on massive hepatocellular carcinoma (MHCC). Methods: TACE was performed in 57 patients with MHCC, which were randomly divided into group A (n = 28) and group B (n = 29). Patients in the group Areceived conventional TACE for the first time and then received low dose TACE (10 mg mitomycin C) for the repeated treatment, Re-examined CT scans after TACE for a week. Based on filled status of Lipiodol in the Lesions, PAI was underwent in the area of rarefaction or defect filled by Lipiodol. Patients in the group B received conventional TACE. Then The survival rate and masses variation and hepatic function and α-FP and side effects were observed. Results: The 1-, 2- and 3-year survival rate after TACE were 96.4%, 78.6%and 32.1% for group A, and 65.5%, 48.3% and 20.7% for group B. Masses diminution were found in all patients in group A, while 20 cases were found in group B, unchanged in 5 cases and enlarged in 4 cases. Conclusion: The efficacy of TACE combined with PAI are significantly better than that of TACE only, low dose TACE produces less hepatic damage and less side effect.