糖尿病患者抗心磷酯抗体检测的临床意义

摘要

测定了50例糖尿病患者的抗心磷酯抗体（ACA）。结果显示：①糖尿病患者ACA阳性率与病程呈正相关（P＜0.05）；②ACA阳性的糖尿病患者血糖、甘油三酯，尿微量白蛋白明显高于ACA阴性的患者（P＜0.05）。③ACA阳性糖尿病患者，高血压、脑梗死、肾病、眼底病变发生率较ACA阴性者有显著差异（P＜0.05）。心肌梗死及高胆固醇血症患者发生率两组无差异（P＞0.5）。提示糖尿病患者易导致免疫功能紊乱。%To study the relationship between chronic complications ofdiabetic patients and immune dysfunction ACA were measured in 50 patients with diabetes.The result showed：①The positive rate of ACA was positively associated with the duration of diabetes（P＝0.05）.②Patients with positive ACA has the higher lovels of blood glucose，triglycerides and urine microalbumin than that of negative ACA（P＜0.05）.③In patiants with positive ACA the rate of hypertension，cerebral infarction nephropathy and eyeground disease were higher than the negative（P＜0.005，P＜0.01，P＜0.05），but the myocardial infarction and hypercholesteroemia has no difference.This suggects that there is immune dysfuncfion in patients with longer duration.