凋亡相关基因bcl-2和bax在肺癌中的表达及意义

摘要

To study the relationship between expression of bcl-2 and baxgene and lung cancer.The bcl-2 and bax gene expression in 51 lung cancer tissues and tissues near cancer were deteeted by immunohistochemical SP method.The positive degree of bcl-2 gene expression in lung cancer was higher than that in tissues near cancer.The positive degree of bax gene expression in lung cancer was lower than that in tissues near cancer.Both differences were very significant（P＜0.01）.There was no correlations between the immunoreactivity of bcl-2 and bax gene and histology，gender，smoking history，clinical subtypes，stage and lymphatic metastasis（P＞0.05）.It suggests that bcl-2 and bax gene may play an important role in tumorgenesis and tumor development.The detection and determination of bcl-2 and bax gene in preinvasive lesions may contribute to the early diagnosis of lung cancer.Some drugs can down-regulate bcl-2 expression and speed apoptosis so as to improve the sensitivity to chemical therapy and radiation.%为探讨B细胞淋巴瘤／白血病-2（bcl-2）基因及其同源类似物bax基因的表达与肺癌发生的关系，应用免疫组化SP法检测了51例肺癌患者的肺癌标本及其癌旁组织中bcl-2、bax的表达。结果显示，bcl-2在肺癌中染色比在癌旁组织中深，bax在肺癌中染色比在癌旁组织中浅，两者之间均有极显著差异（P＜0.01）；bcl-2、bax表达与肺癌的组织分型、患者的性别、吸烟史、临床分型、分期及淋巴结转移无关（P＞0.05）。提示：①bcl-2、bax在肺癌发生中具有重要作用。②在癌前病变组织中检测并比较bcl-2和bax的表达，有利于肺癌的早期诊断。③可通过药物使bcl-2表达降低，促进凋亡，提高患者对放、化疗的敏感性。